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Carboxylic Acid‐Catalysed Transamidation of Boc‐Protected Diketopiperazines (Boc‐DKPs) for Peptide Synthesis
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2024-12-28 , DOI: 10.1002/ejoc.202401319 Kazumasa Kon, Hisashi Yamamoto
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2024-12-28 , DOI: 10.1002/ejoc.202401319 Kazumasa Kon, Hisashi Yamamoto
A carboxylic acid‐catalysed transamidation of Boc‐protected diketopiperazines (Boc‐DKPs) was developed in this study, which allowed access to various tripeptides featuring a D‐proline residue in good‐to‐high yields within 30 min. Subsequent coupling reactions between the Boc‐DKPs and di‐, tri‐, and tetrapeptide esters were successfully performed, furnishing the corresponding tetra‐, penta‐, and hexapeptides.
中文翻译:
用于肽合成的 Boc 保护的二酮哌嗪 (Boc-DKP) 的羧酸催化转酰胺化反应
本研究开发了一种羧酸催化的 Boc 保护二酮哌嗪 (Boc-DKP) 的转酰胺反应,其允许在 30 分钟内以良好到高的产率获得具有 D-脯氨酸残基的各种三肽。随后 Boc-DKP 与二肽酯、三肽酯和四肽酯之间的偶联反应成功进行,提供了相应的四肽、五肽和六肽。
更新日期:2024-12-28
中文翻译:
用于肽合成的 Boc 保护的二酮哌嗪 (Boc-DKP) 的羧酸催化转酰胺化反应
本研究开发了一种羧酸催化的 Boc 保护二酮哌嗪 (Boc-DKP) 的转酰胺反应,其允许在 30 分钟内以良好到高的产率获得具有 D-脯氨酸残基的各种三肽。随后 Boc-DKP 与二肽酯、三肽酯和四肽酯之间的偶联反应成功进行,提供了相应的四肽、五肽和六肽。