Flavonoids are an important class of naturally existing scaffolds known for their diverse biological activities and have been immensely synthesized using stoichiometric reagent amounts. Herein, we report a reliable, robust, one‐pot, transition metal and additive‐free protocol for the synthesis of flavones and flavanones from 2‐hydroxyacetophenone and substituted aldehydes. Our developed method utilizes Cs2CO3 as a base and iodine as an oxidant in H2O: DMSO (9:1) solvent system, which provides direct access to many flavones and flavanones in excellent yields under milder reaction conditions with simple yet easily available substrates. In application, naturally occurring compounds such as naringenin and apigenin have been successfully synthesized using developed protocol.

中文翻译：

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Cs2CO3-I2 促进黄酮和黄烷酮的高效合成：Narengenin 和 Apigenin 的总合成


类黄酮是一类重要的天然存在的支架，以其多种生物活性而闻名，并且已使用化学计量试剂量进行大量合成。在此，我们报告了一种可靠、稳健、一锅法、过渡金属和无添加剂的方案，用于从 2-羟基苯乙酮和取代醛合成黄酮和黄烷酮。我们开发的方法在 H2O：DMSO （9：1） 溶剂系统中利用 Cs 2 CO3 作为碱，碘作为氧化剂，在较温和的反应条件下以极高的产率直接获得许多黄酮和黄烷酮，底物简单但容易获得。在应用中，天然存在的化合物，如柚皮素和芹菜素，已经使用开发的方案成功合成。