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A covalent organic framework-based nanoreactor for enhanced chemodynamic therapy through cascaded fenton-like reactions and nitric oxide delivery
Chemical Communications ( IF 4.3 ) Pub Date : 2024-12-27 , DOI: 10.1039/d4cc05939e Tian Song, Jin-Zhou Lv, Bo Wang, Wen-Yan Li, Bao-Yu Ge, Yan-An Li, Yu-Bin Dong
Chemical Communications ( IF 4.3 ) Pub Date : 2024-12-27 , DOI: 10.1039/d4cc05939e Tian Song, Jin-Zhou Lv, Bo Wang, Wen-Yan Li, Bao-Yu Ge, Yan-An Li, Yu-Bin Dong
Herein, we report a nanoscale composite COF material loaded with copper peroxide (CuO2) and nitric oxide (NO) prodrug via a stepwise post-synthetic modification. The obtained CuO2@COF-SNO can occur a cascade reaction in the tumour microenvironment to generate reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of tumor.
中文翻译:
一种基于共价有机框架的纳米反应器,用于通过级联 fenton 样反应和一氧化氮递送增强化学动力学治疗
在此,我们报道了一种纳米级复合 COF 材料,通过逐步合成后修饰负载过氧化铜 (CuO2) 和一氧化氮 (NO) 前药。获得的 CuO2@COF-SNO 可以在肿瘤微环境中发生级联反应,产生活性氧和氮物质 (ROS/RNS),以增强肿瘤的化疗动力学治疗。
更新日期:2024-12-27
中文翻译:
一种基于共价有机框架的纳米反应器,用于通过级联 fenton 样反应和一氧化氮递送增强化学动力学治疗
在此,我们报道了一种纳米级复合 COF 材料,通过逐步合成后修饰负载过氧化铜 (CuO2) 和一氧化氮 (NO) 前药。获得的 CuO2@COF-SNO 可以在肿瘤微环境中发生级联反应,产生活性氧和氮物质 (ROS/RNS),以增强肿瘤的化疗动力学治疗。