Chirality, the property of objects that are nonsuperimposable on their mirror images, plays a crucial role in biological processes and cellular behaviors. Chiral engineered biomaterials have emerged as a promising approach to regulating cellular fate in regenerative medicine. However, few reviews provide a comprehensive examination of recent advancements in chiral biomaterials and their applications in cellular fate regulation. Herein, various fabrication techniques available for chiral biomaterials, including the use of chiral molecules, surface patterning, and self‐assembly are discussed. The mechanisms through which chiral biomaterials influence cellular responses, such as modulation of adhesion receptors, intracellular signaling, and gene expression, are explored. Notably, chiral biomaterials have demonstrated their ability to guide stem cell differentiation and augment tissue‐specific functions. The potential applications of chiral biomaterials in musculoskeletal disorders, neurodegenerative diseases, cardiovascular diseases, and wound healing are highlighted. Challenges and future perspectives, including standardization of fabrication methods and translation to clinical settings, are addressed. In conclusion, chiral engineered biomaterials offer exciting prospects for precisely controlling cellular fate, advancing regenerative medicine, and enabling personalized therapeutic strategies.

中文翻译：

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手性工程生物材料：再生医学细胞命运调控的新前沿


手性是物体在其镜像上不可叠加的特性，在生物过程和细胞行为中起着至关重要的作用。手性工程生物材料已成为再生医学中调节细胞命运的一种很有前途的方法。然而，很少有综述全面研究手性生物材料的最新进展及其在细胞命运调控中的应用。在本文中，讨论了可用于手性生物材料的各种制造技术，包括手性分子的使用、表面图案化和自组装。探讨了手性生物材料影响细胞反应的机制，例如粘附受体的调节、细胞内信号传导和基因表达。值得注意的是，手性生物材料已证明其能够指导干细胞分化和增强组织特异性功能。强调了手性生物材料在肌肉骨骼疾病、神经退行性疾病、心血管疾病和伤口愈合方面的潜在应用。解决了挑战和未来前景，包括制造方法的标准化和向临床环境的转化。总之，手性工程生物材料为精确控制细胞命运、推进再生医学和实现个性化治疗策略提供了令人兴奋的前景。