A novel Rh(III)‐catalyzed [4+2] annulation of N‐hydroxyoximes with maleate esters/2‐chloroacrylates is disclosed, in which diverse isoquinoline skeleton compounds were generated in moderate to excellent yields. The protocol exhibits a good compatibility of functional groups and wide scope of substrates without using any external metal oxidants. Gram‐scale and derivatization reactions were performed to show the potential utility of this transformation.

中文翻译：

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铑 （III） 催化 [4+2] N-羟基肟与马来酸酯/2-氯丙烯酸酯的环化：异喹啉-3,4-二羧酸盐和异喹啉-3-羧酸盐的合成


公开了一种新的 Rh（III） 催化的 N-羟基肟与马来酸酯/2-氯丙烯酸酯的环化 [4+2]，其中以中等至极高的产率生成了不同的异喹啉骨架化合物。该方案表现出良好的官能团和广泛的底物兼容性，无需使用任何外部金属氧化剂。进行革兰级和衍生化反应以显示这种转化的潜在效用。