The disruption of Cu homeostasis is associated with the pathogenesis of many diseases and can.result in alterations in Cu isotope fractionation. Changes in the Cu isotope ratio (⁶⁵Cu/⁶³Cu) of body fluids and tissues have been observed in liver disorders, cancers, and other diseases, displaying diagnostic/prognostic potential. However, it is not entirely clear whether certain physiological or lifestyle factors may also influence the bodily Cu isotopic composition, potentially obfuscating the signature of the pathology. To ascertain whether differences in Cu isotopic composition exist between food products, the isotopic composition of 29 significant dietary Cu sources have been determined for the first time. The general enrichment of Cu and its heavy isotope, ⁶⁵Cu, in legumes, nuts, and seeds (major Cu sources in plant-based diets) was revealed, suggesting that individuals with plant-based diets may have a bodily Cu isotopic composition offset from that of individuals with omnivorous diets, and require controlling for in study design.

中文翻译：

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通过多收集器 ICP 质谱法对人类膳食 Cu 源进行高精度铜同位素分析


Cu 稳态的破坏与许多疾病的发病机制有关，并可导致 Cu 同位素分馏的改变。在肝脏疾病、癌症和其他疾病中观察到体液和组织的 Cu 同位素比值 （⁶⁵Cu/⁶³Cu） 的变化，显示出诊断/预后潜力。然而，目前尚不完全清楚某些生理或生活方式因素是否也会影响体内的 Cu 同位素组成，从而可能混淆病理特征。为了确定食品之间是否存在 Cu 同位素组成的差异，首次确定了 29 种重要的膳食 Cu 来源的同位素组成。揭示了豆类、坚果和种子（植物性饮食中的主要铜来源）中铜及其重同位素 ⁶⁵Cu 的普遍富集，这表明植物性饮食的个体可能具有与杂食性饮食个体的身体铜同位素组成相抵消，并且需要在研究设计中进行控制。