Huang and coworkers recently demonstrated that a cobalt(I)-hydride complex, ligated with a finely tuned chiral bisoxazoline ligand, can selectively reduce disubstituted malononitriles by discriminating between enantiotopic nitrile groups. This reductive desymmetrisation strategy utilises the bulk industrial feedstock malononitrile to access nitrogen-rich enantioenriched products.

中文翻译：

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注意差距！Steric 驱动的丙二腈还原不对称化


Huang 及其同事最近证明，与精细调整的手性双恶唑啉配体连接的钴 （I） -氢化物复合物可以通过区分对映位腈基团来选择性地还原二取代的丙二腈。这种还原性去对称策略利用散装工业原料丙二腈来获得富含氮的对映体富集产物。