Large segment bone defects pose a significant challenge in the field of orthopedic surgery, requiring effective and innovative approaches for restoration. However, many existing scaffolds are bioinert and do not support crucial processes such as cell adhesion, proliferation, and vascularization. In this study, a dual‐bionic 3D printing bredigite scaffold is developed, featuring a combination of physical structure and bioactive functions. Specifically, the structure‐mimetic scaffold has an isotropic single‐cell structure suitable for defects with varying load‐bearing requirements and allowing the ingrowth of vessels and bone. Meanwhile, an extracellular matrix peptide‐mimetic β‐amino acid polymer DM50CO50 and deferoxamine are modified onto the scaffold simultaneously to promote the adhesion of bone marrow mesenchymal stem cells and vascularization. The dual‐bionic scaffolds demonstrate outstanding osteogenic and angiogenic properties in a rat model with large segment bone defects to promote bone restoration, implying a promising strategy in designing scaffolds to promote osteoconductivity and angiogenesis for large segment bone restoration.

中文翻译：

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3D 打印双仿生支架促进骨传导和血管生成，用于大节段骨修复


大段骨缺损在骨外科领域构成了重大挑战，需要有效和创新的方法进行修复。然而，许多现有的支架是生物惰性的，不支持细胞粘附、增殖和血管形成等关键过程。在这项研究中，开发了一种双仿生 3D 打印 bredigite 支架，其特点是物理结构和生物活性功能相结合。具体来说，结构模拟支架具有各向同性单细胞结构，适用于具有不同承载要求的缺陷，并允许血管和骨骼向内生长。同时，细胞外基质肽模拟物 β-氨基酸聚合物DM50CO50和去铁胺同时修饰到支架上，以促进骨髓间充质干细胞的粘附和血管形成。双仿生支架在具有大节段骨缺损的大鼠模型中表现出出色的成骨和血管生成特性，以促进骨修复，这意味着在设计支架以促进大节段骨修复的骨传导和血管生成方面是一种很有前途的策略。