Metal ions have regulatory activities of multi‐tissue regeneration but usually interrupt early coagulation, resulting in an abnormal hematoma structure that is not conducive to long‐term repair or regeneration. To address free metal ions immobilization during the coagulation phase and effectively promote ionic bioactivities through controlled macrophage uptake after coagulation, metal ion “adjuvants” are required. [Si─O4] tetrahedron has a unique coordination tetrahedral structure to capture various metal ions and adsorb plasma proteins such as fibrinogen to facilitate macrophage uptake via receptor‐mediated endocytosis during the degradation of the fibrin network. Taking advantage of the hypoxia induction and tissue regeneration ability of copper ions, Cu[Si─O4] tetrahedrons are prepared which successfully immobilized copper ions and addressed the coagulation interruption. Cu[Si─O4] tetrahedrons effectively promote copper ionic uptake by macrophages via LRP1‐mediated endocytosis to create a hypoxia microenvironment and promote periodontal multi‐tissue regeneration. Therefore, [Si─O4] tetrahedron is a kind of advanced multifunctional metal ion “adjuvants” that can capture metal ions and assist their transmembrane transporting to address metal ion‐induced coagulation interruption and promote multi‐tissue regeneration, providing a new strategy for metal ion‐mediated biotherapy research.

中文翻译：

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金属离子“佐剂”[Si─O4] 四面体通过智能离子捕获和细胞膜运输解决凝血中断问题并促进多组织再生


金属离子具有多组织再生的调节活性，但通常会中断早期凝血，导致血肿结构异常，不利于长期修复或再生。为了解决凝血阶段的游离金属离子固定问题，并通过凝血后控制巨噬细胞的摄取来有效促进离子生物活性，需要金属离子“佐剂”。[Si─O4] 四面体具有独特的配位四面体结构，可捕获各种金属离子并吸附纤维蛋白原等血浆蛋白，从而在纤维蛋白网络降解过程中通过受体介导的内吞作用促进巨噬细胞摄取。利用铜离子的缺氧诱导和组织再生能力，制备了 Cu[Si─O4] 四面体，成功固定了铜离子并解决了凝血中断问题。Cu[Si─O4] 四面体通过 LRP1 介导的内吞作用有效促进巨噬细胞对铜离子的摄取，从而创造缺氧微环境并促进牙周多组织再生。因此，[Si─O4] 四面体是一种先进的多功能金属离子“佐剂”，可以捕获金属离子并协助其跨膜转运，以解决金属离子诱导的凝血中断问题并促进多组织再生，为金属离子介导的生物治疗研究提供了新的策略。