A facile electrochemical strategy for the synthesis of sulfonylphenol derivatives from N-(4-hydroxyphenyl)-sulfonamides with sulfonyl hydrazides has been successfully developed. This metal- and oxidant-free protocol is suitable for aromatic, heteroaromatic and aliphatic reagents to afford the corresponding sulfonylated products in moderate to high yields under mild conditions. Notably, we successfully scaled up the reaction to gram quantities, underscoring its potential for larger-scale applications. Furthermore, the synthesized sulfonylphenol derivatives exhibited promising in vitro antibacterial activity, highlighting their potential therapeutic relevance.

中文翻译：

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一种用磺酰肼直接磺酰化 N-（4-羟基苯基）-磺酰胺进行磺酰肼化的电化学方法


已成功开发出一种用于从 N-（4-羟基苯基）-磺酰胺与磺酰酰肼合成磺酰基苯酚衍生物的简单电化学策略。这种不含金属和氧化剂的方案适用于芳香族、杂芳族和脂肪族试剂，可在温和条件下以中高产率获得相应的磺酰化产物。值得注意的是，我们成功地将反应放大到克级，强调了其更大规模应用的潜力。此外，合成的磺酰酚衍生物表现出有希望的体外抗菌活性，突出了它们潜在的治疗相关性。