An efficient and pot economic synthetic strategy has been established for the diastereoselective construction of multifunctionalized 3,3′-pyrrolidonyl-spirooxindoles. DFT studies clarified the mechanism of regioselective cascade ring closure, highlighting the preferential reactivity of reduced nitro groups with nitriles, while ester groups remained unreactive.

中文翻译：

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用于多功能 3,3′-吡咯烷基-螺氧吲哚的非对映选择性合成的连续硝基-迈克尔加成和还原环化级联反应


已经建立了一种高效且经济的合成策略，用于多功能化 3,3′-吡咯己烯基-螺氧吲哚的非对映选择性构建。DFT 研究阐明了区域选择性级联环闭合的机制，突出了还原硝基与腈的优先反应性，而酯基保持无反应性。