The BINOL-based unsymmetric chiral dialdehydes are discovered to undergo regioselective as well as enantioselective reactions with an unsymmetric chiral diamine, lysine, to generate unsymmetric chiral macrocycles. Addition of Zn²⁺ can further enhance the selectivity for the macrocycle formation. These compounds are also found to exhibit chemoselective and enantioselective fluorescent recognition of lysine in the presence of Zn²⁺.

中文翻译：

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不对称手性二醛与赖氨酸的反应：区域和对映选择性大环化和荧光传感


发现基于 BINO 的不对称手性二醛与不对称的手性二胺赖氨酸发生区域选择性和对映选择性反应，以产生不对称的手性大环。添加 Zn²⁺ 可以进一步增强大环形成的选择性。还发现这些化合物在 Zn²⁺ 存在下表现出对赖氨酸的化学选择性和对映选择性荧光识别。