A series of 4(3H)-quinazolinones with variable steric and electronic features were synthesized with good to excellent yields by trimethylsilylpolyphosphate (PPSE) promoted reaction of secondary amides and methyl anthranilates. The reaction is metal and ligand free, involving easily available starting materials, and suitable for scaling up. The one pot modification, which comprises 2 or 3 steps, was also efficient.

中文翻译：

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聚磷酸三甲基硅烷基促进邻氨基苯甲酸甲酯 4（3H）-喹唑啉酮的高效合成


通过三甲基硅烷基聚磷酸酯 （PPSE） 促进仲酰胺和邻氨基苯甲酸甲酯的反应，合成了一系列具有不同空间和电子特性的 4（3H）-喹唑啉酮，产率从好到极好。该反应不含金属和配体，涉及容易获得的起始材料，适合放大。包括 2 或 3 个步骤的单罐改性也很有效。