Microreactors provide an enhanced mixing performance but suffer from low throughput. This work proposed a macro-microreactor with designed internals to achieve both process intensification and scale-up for the liquid–liquid homogeneous chemical processes. Numerical simulations utilizing computational fluid dynamics were conducted to investigate the fluid mechanics and the properties of mixing of a macro-microreactor (feature size >2000 μm). Experimental validation using the Villermaux–Dushman reaction demonstrated that this easily fabricated macro-microreactor with optimized helical-shaped internal achieved a comparable mixing performance, lower pressure drop, and higher throughput compared to a typical microreactor with a smaller feature size (1000 μm). The macro-microreactor would find more applications in industrial liquid–liquid homogeneous chemical processes.

中文翻译：

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基于宏观微反应器的工艺强化，实现高混合性能、低压降和高通量的液-液均相化学工艺


微反应器提供增强的混合性能，但吞吐量低。这项工作提出了一种具有设计内部结构的大微反应器，以实现液-液均相化学过程的工艺强化和放大。利用计算流体动力学进行了数值模拟，以研究宏观微反应器（特征尺寸 >2000 μm）的流体力学和混合特性。使用 Villermaux-Dushman 反应的实验验证表明，与具有较小特征尺寸 （1000 μm） 的典型微反应器相比，这种易于制造的宏观微反应器具有优化的螺旋形内部，实现了相当的混合性能、更低的压降和更高的通量。宏观微反应器将在工业液-液均相化学过程中得到更多应用。