The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence and lipid peroxidation, represents a specialized form of cell death. A burgeoning collection of studies has demonstrated that the cGAS-STING signaling pathway participates in the homeostatic regulation of the organism by modulating ferroptosis-associated enzyme activity or gene expression. Consequently, elucidating the specific roles of the STING signaling pathway and ferroptosis in vivo is vital for targeted disease intervention. This review systematically examines the interactions between the cGAS-STING signaling pathway and ferroptosis, highlighting their influence on disease progression in the contexts of inflammation, injury, and cancerous cell dynamics. Understanding these interactions may provide novel therapeutic strategies. The STING pathway has been implicated in the regulation of various cell death mechanisms, including apoptosis, pyroptosis, necroptosis, autophagy, and ferroptosis. Our focus primarily addresses the role and mechanism of the cGAS-STING signaling pathway and ferroptosis in diseases, limiting discussion of other cell death modalities and precluding a comprehensive overview of the pathway’s additional functions.

中文翻译：

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cGAS-STING 信号通路在铁死亡中的作用


干扰素基因的环状 GMP-AMP 合酶 （cGAS） 刺激剂 （STING） 信号通路已被确定为抗病毒防御和先天免疫通路的关键机制。铁死亡以铁依赖和脂质过氧化为特征，代表了细胞死亡的一种特殊形式。大量研究表明，cGAS-STING 信号通路通过调节铁死亡相关酶活性或基因表达参与生物体的稳态调节。因此，阐明体内 STING 信号通路和铁死亡的具体作用对于靶向疾病干预至关重要。本综述系统地研究了 cGAS-STING 信号通路与铁死亡之间的相互作用，强调了它们在炎症、损伤和癌细胞动力学背景下对疾病进展的影响。了解这些相互作用可能会提供新的治疗策略。STING 通路与各种细胞死亡机制的调节有关，包括细胞凋亡、焦亡、坏死性凋亡、自噬和铁死亡。我们的重点主要涉及 cGAS-STING 信号通路和铁死亡在疾病中的作用和机制，限制了对其他细胞死亡方式的讨论，并排除了对该通路附加功能的全面概述。