Monitoring electrical potentials with high recording site density and micrometer spatial resolution in liquid is critical in biosensing. Organic electronic materials have driven remarkable advances in the field because of their unique material properties, yet limitations in spatial resolution and recording density remain. Here, we introduce organic electro-scattering antennas (OCEANs) for wireless, light-based probing of electrical signals with micrometer spatial resolution, potentially from thousands of sites. The technology relies on the unique dependence of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate light scattering properties to its doping level. Electro-optic characteristics of individual antennas varying in diameters and operating voltages were systematically characterized in saline solution. Signal-to-noise ratios up to 48 were achieved in response to 100-mV stimuli, with 2.5-mV detection limits. OCEANs demonstrated millisecond time constants and exceptional long-term stability, enabling continuous recordings over 10 hours. By offering spatial resolution of 5 μm and a recording density of 4 × 10 6 cm −2 , OCEANs unlock new readout capabilities, potentially accelerating fundamental and clinical research.

中文翻译：

---

有机电散射天线：具有高空间分辨率的无线和多站点电势探测


在生物传感中，以高记录位点密度和微米空间分辨率监测液体中的电势至关重要。有机电子材料因其独特的材料特性而推动了该领域的显着进步，但空间分辨率和记录密度仍然存在限制。在这里，我们介绍了有机电散射天线 （OCEAN），用于以微米级空间分辨率对电信号进行无线、基于光的探测，可能来自数千个站点。该技术依赖于聚（3,4-乙烯二氧噻吩）:p olystyrene sulfonate 光散射特性对其掺杂水平的独特依赖性。在盐溶液中系统地表征了直径和工作电压不同的单个天线的电光特性。响应 100 mV 刺激，信噪比高达 48，检测限为 2.5 mV。OCEANs 表现出毫秒级的时间常数和卓越的长期稳定性，能够连续记录超过 10 小时。通过提供 5 μm 的空间分辨率和 4 × 10 6 cm −2 的记录密度，OCEANs 解锁了新的读出功能，有可能加速基础和临床研究。