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Blocking CDK7 attenuates inflammatory arthritis
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2024-12-20 , DOI: 10.1038/s41584-024-01211-8
Sarah Onuora

In a new study, inhibition of CDK7 disrupted the RNA polymerase II transcription cycle, leading to anti-inflammatory effects and metabolic reprogramming in macrophages and attenuation of arthritis in mouse models.

中文翻译:


阻断 CDK7 可减轻炎症性关节炎



在一项新研究中,CDK7 的抑制破坏了 RNA 聚合酶 II 转录周期,导致巨噬细胞中的抗炎作用和代谢重编程,并在小鼠模型中减轻关节炎。
更新日期:2024-12-21
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