Sickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD) and can drastically impair visual acuity. Screening for SCR is therefore recommended, but evidence for optimal screening frequency on an individual level is lacking. This scoping review mapped the current evidence on risk factors for SCR and sickle cell maculopathy (SCM). A literature search (in Medline(Ovid), Embase(Ovid) and Scopus) resulted in 67 included articles, which covered demographic risk factors, genetic risk factors, systemic therapy, correlations with other forms of SCD-related organ damage and hematological risk factors. SCR risk factors include older age, male sex, HbSC genotype, hemolysis and HbF% 15%) patients to ensure comprehensive yet proportionate ophthalmic care. However, to elucidate the sense and nonsense of screening, future studies are needed on the role of interventions for SCR and the long-term consequences of SCM.

中文翻译：

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镰状细胞性视网膜病变和黄斑病变的临床和实验室危险因素：当前证据的范围审查。


镰状细胞视网膜病变 （SCR） 是镰状细胞病 （SCD） 的并发症，可严重损害视力。因此，建议进行 SCR 筛查，但缺乏个体层面最佳筛查频率的证据。本范围综述绘制了 SCR 和镰状细胞黄斑病变 （SCM） 危险因素的当前证据。文献检索 （在 Medline（Ovid）、Embase（Ovid） 和 Scopus 中）共纳入 67 篇文章，涵盖人口学危险因素、遗传危险因素、全身治疗、与其他形式的 SCD 相关器官损伤的相关性以及血液学危险因素。SCR 危险因素包括高龄、男性、HbSC 基因型、溶血和 HbF% 15%） 患者，以确保全面而相称的眼科护理。然而，为了阐明筛查的意义和无意义，需要进一步研究干预措施对 SCR 的作用和 SCM 的长期后果。