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Enantioselective Intermolecular Benzylic C–H Amination under Chiral Paddle-Wheel Diruthenium Catalysis
ACS Catalysis ( IF 11.3 ) Pub Date : 2024-12-20 , DOI: 10.1021/acscatal.4c06504 Kotoko Makino, Kohei Mori, Shoichi Kiryu, Taku Miyazawa, Yuhei Kumagai, Kosuke Higashida, Masahiro Kojima, Tatsuhiko Yoshino, Shigeki Matsunaga
ACS Catalysis ( IF 11.3 ) Pub Date : 2024-12-20 , DOI: 10.1021/acscatal.4c06504 Kotoko Makino, Kohei Mori, Shoichi Kiryu, Taku Miyazawa, Yuhei Kumagai, Kosuke Higashida, Masahiro Kojima, Tatsuhiko Yoshino, Shigeki Matsunaga
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A catalytic asymmetric intermolecular benzylic C–H amination was achieved under paddle-wheel diruthenium catalysis. A chiral diruthenium catalyst incorporating (S)-TPPTTL (tetraphenylphthaloyl-(S)-tert-leucine) ligand exhibited notable enantioselectivity, and aminated products were obtained with up to 99% ee. Unique chemoselectivity of the chiral diruthenium catalyst was also found for allylbenzene and alkyl-naphthalene substrates, demonstrating the complementary synthetic utility of chiral paddle-wheel Ru(II)–Ru(III) catalysts to Rh(II) counterparts.
更新日期：2024-12-20
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