The treatment of wounds in subtropical coastal areas presents unique environmental challenges. Infection prevention, light-induced damage management, and wound fluid control are crucial considerations for effective wound healing. Herein, this study aimed to fabricate a novel bilayered Janus wound dressing by in situ electrospinning technology, designed to exhibit excellent resistance to UV radiation, robust antibacterial property, and efficient fluid management capability. To realize the directional liquid transport function of Janus bilayer dressing, we selected a poly(vinyl butyral) (PVB) hydrophobic inner layer and a poly(vinyl alcohol) (PVA) hydrophilic outer layer as the base material. Antibacterial drugs were introduced through the PVB layer, with the aim of achieving antibacterial function. SiO₂ was introduced through the PVA layer to realize the antiultraviolet radiation effect. By adjusting the amount of drug and SiO₂, multifunctional PVB@Amp&PVA@SiO₂ composite dressings were systemically optimized with good antibacterial properties (more than 96% against both Escherichia coli and Staphylococcus aureus), excellent resistance to ultraviolet radiation (UPF up to 55.78), and unidirectional exudate exportation of tissue fluid from the wound to the outside world in 4 min. Moreover, the composite dressing had good biocompatibility, including a 95.64% cell survival rate and a 0.0929% hemolysis rate. This study provided a promising new option for antibacterial and ultraviolet radiation protection in subtropical coastal environments with promising applications in outdoor first aid, wound care, and military products.

中文翻译：

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具有抗菌活性、紫外线辐射防护和定向液体传输特性的复合 Janus 纳米纤维膜的原位静电纺丝


亚热带沿海地区的伤口治疗面临独特的环境挑战。感染预防、光诱导损伤管理和伤口液体控制是有效伤口愈合的关键考虑因素。在此，本研究旨在通过原位静电纺丝技术制造一种新型双层 Janus 伤口敷料，旨在表现出优异的抗紫外线辐射性、强大的抗菌性能和高效的流体管理能力。为了实现 Janus 双层敷料的定向液体传输功能，我们选择了聚乙烯基缩丁醛 （PVB） 疏水内层和聚乙烯醇 （PVA） 亲水外层作为基材。通过 PVB 层引入抗菌药物，目的是实现抗菌功能。SiO₂ 通过 PVA 层引入以实现抗紫外线辐射效果。通过调节药物和 SiO₂ 的用量，系统优化了多功能 PVB@Amp&PVA@SiO₂ 复合敷料，具有良好的抗菌性能（对大肠杆菌和金黄色葡萄球菌均超过 96%），优异的抗紫外线辐射性（UPF 高达 55.78），并在 4 分钟内组织液从伤口单向渗出到外界。此外，复合敷料具有良好的生物相容性，细胞存活率为 95.64%，溶血率为 0.0929%。这项研究为亚热带沿海环境中的抗菌和紫外线辐射防护提供了一种有前途的新选择，在户外急救、伤口护理和军用产品方面具有广阔的应用前景。