This work covers a Mg–Zn–Ca–Pr alloy fabricated by a novel method of mechanical alloying and spark plasma sintering (SPS). Currently, magnesium alloys used as biomaterials are mostly commercial alloys without consideration of cytotoxicity from the perspective of biosafety. So far, the tribological and cytotoxic properties of Mg–Zn–Ca–Pr alloys have not been investigated. Hence, in the article, the tribological properties, considering wear rate, wear resistance, coefficient of friction, and the roughness of the sintered Mg–Zn–Ca–Pr alloy, are investigated. Cytotoxicity assays have also been carried out. The ball-on-a-disc method is used in the tribological test. Samples before sintering by the SPS method are milled at varying times of 13, 20, and 70 h. Results show that increasing the milling time affects tribology and cytotoxic tests. The longer the milling time, the lower the cell survival rate. The conducted tests reveal cell survival of 90, 82, and 61% for 13, 20, and 70 h, respectively. A reduction of cell viability by over 30% is considered a cytotoxic effect, which was observed only in the 70 h milling-time samples.

中文翻译：

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生物相容性 Mg-Zn-Ca-Pr 合金的摩擦学和细胞毒性分析分析


这项工作涵盖了通过机械合金化和放电等离子烧结 （SPS） 的新方法制造的 Mg-Zn-Ca-Pr 合金。目前，用作生物材料的镁合金多为商业合金，从生物安全性的角度不考虑细胞毒性。到目前为止，尚未研究 Mg-Zn-Ca-Pr 合金的摩擦学和细胞毒性特性。因此，在本文中，研究了考虑磨损率、耐磨性、摩擦系数和烧结 Mg-Zn-Ca-Pr 合金粗糙度的摩擦学性能。还进行了细胞毒性测定。球盘法用于摩擦学测试。通过 SPS 方法烧结前的样品在 13、20 和 70 小时的不同时间研磨。结果表明，增加铣削时间会影响摩擦学和细胞毒性测试。研磨时间越长，细胞存活率越低。进行的测试显示，细胞存活率分别为 90、82 和 61%，持续 13 、 20 和 70 小时。细胞活力降低超过 30% 被认为是一种细胞毒作用，这仅在 70 小时研磨时间的样品中观察到。