Cloud computing allows storing the ever-growing genotype-phenotype datasets crucial for precision medicine. Due to the sensitive nature of this data and varied laws and regulations, additional security measures are needed to ensure data privacy. We develop SQUiD, a secure queryable database for storing and analyzing genotype-phenotype data. SQUiD allows storage and secure querying of data in a low-security, low-cost public cloud using homomorphic encryption in a multi-client setting. We demonstrate SQUiD’s practical usability and scalability using synthetic and UK Biobank data.

中文翻译：

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SQUiD：超安全的遗传数据存储和分析，推动精准医疗的发展


云计算允许存储不断增长的基因型-表型数据集，这对精准医疗至关重要。由于这些数据的敏感性和不同的法律法规，需要额外的安全措施来确保数据隐私。我们开发了 SQUiD，这是一个安全的可查询数据库，用于存储和分析基因型-表型数据。SQUiD 允许在多客户端设置中使用同态加密，在低安全性、低成本的公共云中存储和安全地查询数据。我们使用合成和英国生物样本库数据来展示 SQUiD 的实际可用性和可扩展性。