Combinatorial networks of cell adhesion molecules and cell surface receptors drive fundamental aspects of neural circuit establishment and function. However, the intracellular signals orchestrated by these cell surface complexes remain less understood. Here, we report that the Gα12/13 pathway lies downstream of several GPCRs with critical synaptic functions. Impairment of the Gα12/13 pathway in postnatal hippocampal neurons diminishes inhibitory inputs without altering neuronal morphology or excitatory transmission. Gα12/13 signaling in hippocampal CA1 neurons in vivo selectively regulates PV interneuron synaptic connectivity, supporting an inhibitory synapse subtype-specific function of this pathway. Our studies establish Gα12/13 as a signaling node that shapes inhibitory hippocampal circuitry.

中文翻译：

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突触 Gα12/13 信号传导建立海马 PV 抑制回路


细胞粘附分子和细胞表面受体的组合网络驱动神经回路建立和功能的基本方面。然而，由这些细胞表面复合物编排的细胞内信号仍然不太清楚。在这里，我们报道了 Gα12/13 通路位于几个具有关键突触功能的 GPCR 的下游。出生后海马神经元中 Gα12/13 通路的损伤减少了抑制输入，而不会改变神经元形态或兴奋性传递。体内海马 CA1 神经元中的 Gα12/13 信号转导选择性调节 PV 中间神经元突触连接，支持该通路的抑制性突触亚型特异性功能。我们的研究确定 Gα12/13 是塑造抑制性海马回路的信号节点。