Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune regulatory cells in pain is unknown. Our objective was to identify synovial innate immune cell subsets and pathophysiologic mechanisms associated with worse pain in patients with knee OA.

中文翻译：

---

滑膜先天免疫衰竭与膝骨关节炎疼痛加剧有关


不受控制的疼痛仍然是膝骨关节炎 （OA） 管理的主要临床挑战，膝骨关节炎 （OA） 是最常见的致残性关节疾病。更严重的疼痛与滑膜先天免疫细胞浸润（滑膜炎）有关，但先天免疫调节细胞在疼痛中的作用尚不清楚。我们的目的是确定膝关节 OA 患者滑膜先天免疫细胞亚群和与加重疼痛相关的病理生理机制。