The Front Cover illustrates two main methodologies of the C−H functionalization of cubanes: directed ortho-metalation (left) and radical functionalization (right). The design is inspired by “Chinchirorin”, a traditional Japanese dice game. In the picture, the dice (the cubanes) are rolled into a pot (a reaction flask). This illustration shows that hand throwing (a metaphor for a catalytic methodology) the cubane into a reaction pot enables precise C−H functionalization of cubane. More information can be found in the Concept by M. Hosaka, S. Nagasawa and Y. Iwabuchi (DOI: 10.1002/ejoc.202401055).

中文翻译：

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封面：古巴化合物 C-H 官能化策略：从化学计量反应到催化方法 （Eur. J. Org. Chem. 46/2024）


封面说明了立方烷 C-H 官能团化的两种主要方法：定向正交金属化（左）和自由基官能团化（右）。该设计的灵感来自日本传统的骰子游戏“Chinchirorin”。在图片中，骰子（立方体）被卷入一个罐子（反应瓶）中。该插图表明，将立方烷手动扔进（催化方法的隐喻）到反应罐中可以实现立方烷的精确 C-H 官能化。更多信息可以在 M. Hosaka、S. Nagasawa 和 Y. Iwabuchi 的概念中找到 （DOI： 10.1002/ejoc.202401055）。