We reported, herein, the fabrication of a Cu(II) Schiff base metal complex, immobilized on chitosan surface coated on NiFe₂O₄ MNPs, intended as a novel heterogeneous and magnetically recyclable nanocatalyst, NiFe₂O₄@CS@CuSB. The synthesis process starts with the preparation of NiFe₂O₄ MNPs followed by coating with chitosan and then subsequent immobilization of the Cu(II) Schiff base metal complex on its surface. Through comprehensive characterization of the prepared nanocatalyst using FT-IR, PXRD, SEM, EDS, TEM, SAED, VSM, BET, XPS, and ICP-AES, the structure, surface morphology, elemental composition, and characteristics of the catalyst are revealed. For the evaluation of its catalytic activity, NiFe₂O₄@CS@CuSB, has been utilized as a potential nanocatalyst for the one-pot multicomponent organic synthesis of 1-amidoalkyl-2-naphthol scaffolds. A straightforward, effective, one-pot, and environmentally safe synthesis of 1-amidoalkyl-2-naphthol has been accomplished using a broad range of aldehydes, 2-naphthol, urea, or amide, demonstrating the catalyst's strong resistance to different functionalities. High yields of the intended products have been obtained without the formation of byproducts. A hot filtration test was employed to evaluate the heterogeneity of the solid nanocatalyst. With potential uses in medicinal chemistry, this novel catalyst presents a viable method for the effective production of bioactive molecules.

中文翻译：

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锚定NiFe2O4@Chitosan的合理设计的 Cu（II） 席夫贱金属配合物：一种高效的非均相和磁可回收的杂化纳米催化剂，用于生物活性 1-酰胺烷基-2-萘酚的一锅多组分合成


我们在本文中报道了 Cu（II） 席夫贱金属配合物的制备，该配合物固定在涂有 NiFe2O4 MNP 的壳聚糖表面上，旨在作为一种新型非均相和可磁性回收的纳米催化剂，NiFe2O4@CS@CuSB。合成过程从制备 NiFe2O4 MNP 开始，然后用壳聚糖包覆，然后随后将 Cu（II） 席夫贱金属络合物固定在其表面。通过使用 FT-IR、PXRD、SEM、EDS、TEM、SAED、VSM、BET、XPS 和 ICP-AES 对制备的纳米催化剂进行全面表征，揭示了催化剂的结构、表面形貌、元素组成和特性。为了评价其催化活性，NiFe2O4@CS@CuSB已被用作一锅法多组分有机合成 1-酰胺烷基-2-萘酚支架的潜在纳米催化剂。使用多种醛类、2-萘酚、尿素或酰胺，实现了简单、有效、一锅法且环保的 1-酰胺基-2-萘酚合成，证明了该催化剂对不同官能团的强烈耐受性。在没有形成副产品的情况下获得了预期产品的高产量。采用热过滤试验来评估固体纳米催化剂的异质性。这种新型催化剂在药物化学中具有潜在用途，为有效生产生物活性分子提供了一种可行的方法。