A concise synthesis of the complex diterpene azorellolide, inspired by speculations on biosynthetic cationic cascades, is presented. The approach, guided by computation, relies on the intramolecular interception of a cyclopropylcarbinyl cation by an appended carboxylate. The successful execution of this strategy was achieved through acid-catalyzed isomerization of a β-lactone in competition with a type I dyotropic rearrangement.

中文翻译：

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通过环丙基甲酰阳离子化学仿生合成 Azorellolide


提出了络合二萜氮杂内酯的简明合成，其灵感来自对生物合成阳离子级联反应的推测。该方法以计算为指导，依赖于附加的羧酸盐对环丙基甲酰阳离子的分子内拦截。该策略的成功执行是通过 β-内酯的酸催化异构化与 I 型二嗜性重排竞争来实现的。