Heavy metals in medicine are easily introduced during production and processing, and heavy metals pose a risk to human health. To realize the separation of heavy metals from medicine and provide a new method for removing heavy metals, in this study, ethylenediaminetetraacetic acid (EDTA) was used to modify chitosan, and the ethylenediaminetetraacetic acid-modified chitosan (CS-EDTA) fiber membrane was prepared through electrospinning to remove lead ions from Coptidis rhizoma decoction. The effects of spinning speed (0.1 mL/h), modification method (2 g Na₂EDTA, 0.1 g EDC, 0.2 g NHS), and pH (pH = 5) on the adsorption capacity were studied. The results showed that the adsorption of Pb²⁺ on the CS-EDTA membrane was pseudo-second-order kinetics model (R² > 0.999) and the Langmuir model (R² > 0.978). The kinetic maximum adsorption capacity of the CS-EDTA membrane was 116.2 mg·g^–1. The Pb²⁺ content in C. rhizoma decoction after adsorption meets the limit requirements for heavy metals specified in the traditional Chinese medicine standard (Pb²⁺ ≤ 5 mg·kg^–1). The chemical composition of the decoction of C. rhizoma did not change significantly after the removal of Pb²⁺. The membrane has antibacterial properties against Gram-negative bacteria.

中文翻译：

---

改性壳聚糖纳米纤维膜制备去除黄连根瘤汤中 Pb2+


医药中的重金属在生产和加工过程中容易引入，重金属对人体健康构成风险。为实现重金属与药物的分离，提供去除重金属的新方法，本研究采用乙二胺四乙酸（EDTA）对壳聚糖进行改性，并通过静电纺丝制备乙二胺四乙酸改性壳聚糖（CS-EDTA）纤维膜，以去除黄连根瘤汤中的铅离子。研究了纺丝速度 （0.1 mL/h）、改性方法 （2 g Na₂EDTA、0.1 g EDC、0.2 g NHS） 和 pH 值 （pH = 5） 对吸附能力的影响。结果表明，Pb²⁺ 在 CS-EDTA 膜上的吸附为准二级动力学模型 （R² > 0.999） 和 Langmuir 模型 （R² > 0.978）。CS-EDTA 膜的动力学最大吸附容量为 116.2 mg·g^–1。吸附后根瘤梭菌汤剂中 Pb²⁺ 含量满足中药标准规定的重金属限量要求 （Pb²⁺ ≤ 5 mg·kg^–1）。去除 Pb²⁺ 后，C. rhizoma 汤剂的化学成分没有显着变化。该膜对革兰氏阴性菌具有抗菌特性。