Neisseria meningitidis is a common commensal bacterium of the nasopharynx that can cause invasive meningococcal disease (IMD). In comparison, N. gonorrhoeae is always a pathogen usually limited to mucosal sites. However, increased evidence for overlapping clinical syndromes is emerging. We compared N. meningitidis samples from a urogenital outbreak in Australia with sequences from the United States and other countries. We conducted phylogenetic analyses to assess relatedness and examine for genomic changes associated with meningococcal adaptation; we collated a total of 255 serogroup Y (MenY), sequence type (ST) 1466 isolate assemblies. Most urogenital isolates originated from Australia; those isolates formed a distinct clade, most closely related genomically to recent US IMD isolates. No specific genomic changes suggested niche adaptation or associated clinical manifestations. The MenY ST1466 N. meningitidis isolates circulating in Australia and the United States are capable of causing both urethritis and invasive meningococcal disease.

脑膜炎奈瑟菌是一种常见的鼻咽共生细菌，可引起侵袭性脑膜炎球菌病 （IMD）。相比之下，淋病奈瑟菌始终是一种病原体，通常局限于粘膜部位。然而，越来越多的重叠临床综合征的证据正在出现。我们将来自澳大利亚泌尿生殖系统暴发的 N.meningitidis 样本与来自美国和其他国家/地区的序列进行了比较。我们进行了系统发育分析，以评估相关性并检查与脑膜炎球菌适应相关的基因组变化;我们共整理了 255 个血清型 Y （MenY），序列型 （ST） 1466 个分离株组装。大多数泌尿生殖系统分离株起源于澳大利亚;这些分离株形成了一个独特的分支，在基因组上与最近的 US IMD 分离株最密切相关。没有特定的基因组变化表明生态位适应或相关的临床表现。在澳大利亚和美国传播的 MenY ST1466 脑膜炎奈瑟菌分离株能够引起尿道炎和侵袭性脑膜炎球菌病。