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Amidine-functionalized aggregation-induced emission luminogen and a 3D-printed digital sensor platform for ultrafast and visual detection of heparin
Analytica Chimica Acta ( IF 5.7 ) Pub Date : 2024-12-18 , DOI: 10.1016/j.aca.2024.343564
Feilong Tang, Siyu Shi, Chiyuan Wei, Yuanqiang Sun, Ran Yang, Lingbo Qu, Zhaohui Li

Heparin is a widely used anticoagulant in clinic. However, improper dosing can increase the risk of thromboembolic events, potentially leading to life-threatening complications. Clinic monitoring of heparin is very important for its use safety. Rapid and accurate point-of-care testing can significantly reduce the risk of thrombotic events. The detection of heparin using fluorescent probes has emerged as a significant area of research, driven by the need for rapid, sensitive, and selective methods for monitoring this crucial anticoagulant in clinical settings. However, the absence of convenient and user-friendly heparin testing methods continues to pose a challenge.

中文翻译:


脒功能化聚集诱导发射发光原和 3D 打印数字传感器平台,用于肝素的超快速和视觉检测



肝素是临床上广泛使用的抗凝剂。然而,剂量不当会增加血栓栓塞事件的风险,可能导致危及生命的并发症。肝素的临床监测对其使用安全性非常重要。快速准确的即时检测可以显著降低血栓形成事件的风险。使用荧光探针检测肝素已成为一个重要的研究领域,因为需要快速、灵敏和选择性的方法来在临床环境中监测这种关键的抗凝剂。然而,缺乏方便且用户友好的肝素检测方法仍然构成挑战。
更新日期:2024-12-18
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