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Effectiveness of ceftazidime–avibactam versus ceftolozane–tazobactam for multidrug-resistant Pseudomonas aeruginosa infections in the USA (CACTUS): a multicentre, retrospective, observational study
The Lancet Infectious Diseases ( IF 36.4 ) Pub Date : 2024-12-16 , DOI: 10.1016/s1473-3099(24)00648-0 Ryan K Shields PharmD, Prof Lilian M Abbo MD, Renee Ackley PharmD, Samuel L Aitken PharmD, Benjamin Albrecht PharmD, Ahmed Babiker MBBS, Rachel Burgoon PharmD, Renzo Cifuentes MD, Kimberly C Claeys PharmD, Brooke N Curry PharmD, Kathryn E DeSear PharmD, Prof Jason C Gallagher PharmD, Esther Y Golnabi PharmD, Alan E Gross PharmD, Jonathan Hand MD, Prof Emily L Heil PharmD, Krutika M Hornback PharmD, Prof Keith S Kaye MD, Trieu-Vi Khuu BS, Megan E Klatt PharmD, Ellen G Kline MS, Ryan C Kubat DO, Wesley D Kufel PharmD, Jae Hyoung Lee MD, Alexander J Lepak MD, Ahmi Lim PharmD, Justin M Ludwig MA, Prof Conan Macdougall PharmD, Anjali Majumdar MD, Amy J Mathers MD, Erin K McCreary PharmD, William R Miller MD, Marguerite L Monogue PharmD, W Justin Moore PharmD, Shannon Olson PharmD, Jessica Oxer BS, Jeffrey C Pearson PharmD, Christine Pham PharmD, Paulette Pinargote MD, Christopher Polk MD, Michael J Satlin MD, Sarah W Satola PhD, Sunish Shah PharmD, Pranita D Tamma MD, Truc T Tran MD, Prof David van Duin MD, Mollie VanNatta PharmD, Ana Vega PharmD, Veena Venugopalan PharmD, Michael P Veve PharmD, Walaiporn Wangchinda MD, Lucy S Witt MD, Janet Y Wu PharmD, Prof Jason M Pogue PharmD, PRECEDENT Network, Ryan K Shields, Lilian M Abbo, Renee Ackley, Samuel L Aitken, Benjamin Albrecht, Ahmed Babiker, Rachel Burgoon, Renzo Cifuentes, Kimberly C Claeys, Brooke N Curry, Kathryn E DeSear, Jason C Gallagher, Esther Y Golnabi, Alan E Gross, Jonathan Hand, Emily L Heil, Krutika M Hornback, Keith S Kaye, Trieu-Vi Khuu, Megan E Klatt, Ellen G Kline, Ryan C Kubat, Wesley D Kufel, Jae Hyoung Lee, Alexander J Lepak, Ahmi Lim, Justin M Ludwig, Conan Macdougall, Anjali Majumdar, Amy J Mathers, Erin K McCreary, William R Miller, Marguerite L Monogue, W Justin Moore, Shannon Olson, Jessica Oxer, Jeffrey C Pearson, Christine Pham, Paulette Pinargote, Christopher Polk, Michael J Satlin, Sarah W Satola, Sunish Shah, Pranita D Tamma, Truc T Tran, David van Duin, Mollie VanNatta, Ana Vega, Veena Venugopalan, Michael P Veve, Walaiporn Wangchinda, Lucy S Witt, Janet Y Wu, Jason M Pogue
The Lancet Infectious Diseases ( IF 36.4 ) Pub Date : 2024-12-16 , DOI: 10.1016/s1473-3099(24)00648-0 Ryan K Shields PharmD, Prof Lilian M Abbo MD, Renee Ackley PharmD, Samuel L Aitken PharmD, Benjamin Albrecht PharmD, Ahmed Babiker MBBS, Rachel Burgoon PharmD, Renzo Cifuentes MD, Kimberly C Claeys PharmD, Brooke N Curry PharmD, Kathryn E DeSear PharmD, Prof Jason C Gallagher PharmD, Esther Y Golnabi PharmD, Alan E Gross PharmD, Jonathan Hand MD, Prof Emily L Heil PharmD, Krutika M Hornback PharmD, Prof Keith S Kaye MD, Trieu-Vi Khuu BS, Megan E Klatt PharmD, Ellen G Kline MS, Ryan C Kubat DO, Wesley D Kufel PharmD, Jae Hyoung Lee MD, Alexander J Lepak MD, Ahmi Lim PharmD, Justin M Ludwig MA, Prof Conan Macdougall PharmD, Anjali Majumdar MD, Amy J Mathers MD, Erin K McCreary PharmD, William R Miller MD, Marguerite L Monogue PharmD, W Justin Moore PharmD, Shannon Olson PharmD, Jessica Oxer BS, Jeffrey C Pearson PharmD, Christine Pham PharmD, Paulette Pinargote MD, Christopher Polk MD, Michael J Satlin MD, Sarah W Satola PhD, Sunish Shah PharmD, Pranita D Tamma MD, Truc T Tran MD, Prof David van Duin MD, Mollie VanNatta PharmD, Ana Vega PharmD, Veena Venugopalan PharmD, Michael P Veve PharmD, Walaiporn Wangchinda MD, Lucy S Witt MD, Janet Y Wu PharmD, Prof Jason M Pogue PharmD, PRECEDENT Network, Ryan K Shields, Lilian M Abbo, Renee Ackley, Samuel L Aitken, Benjamin Albrecht, Ahmed Babiker, Rachel Burgoon, Renzo Cifuentes, Kimberly C Claeys, Brooke N Curry, Kathryn E DeSear, Jason C Gallagher, Esther Y Golnabi, Alan E Gross, Jonathan Hand, Emily L Heil, Krutika M Hornback, Keith S Kaye, Trieu-Vi Khuu, Megan E Klatt, Ellen G Kline, Ryan C Kubat, Wesley D Kufel, Jae Hyoung Lee, Alexander J Lepak, Ahmi Lim, Justin M Ludwig, Conan Macdougall, Anjali Majumdar, Amy J Mathers, Erin K McCreary, William R Miller, Marguerite L Monogue, W Justin Moore, Shannon Olson, Jessica Oxer, Jeffrey C Pearson, Christine Pham, Paulette Pinargote, Christopher Polk, Michael J Satlin, Sarah W Satola, Sunish Shah, Pranita D Tamma, Truc T Tran, David van Duin, Mollie VanNatta, Ana Vega, Veena Venugopalan, Michael P Veve, Walaiporn Wangchinda, Lucy S Witt, Janet Y Wu, Jason M Pogue
Ceftolozane–tazobactam and ceftazidime–avibactam are preferred treatment options for multidrug-resistant Pseudomonas aeruginosa infections; however, real-world comparative effectiveness studies are scarce. Pharmacokinetic and pharmacodynamic differences between the agents might affect clinical response rates. We aimed to compare the effectiveness of ceftolozane–tazobactam and ceftazidime–avibactam for treatment of invasive multidrug-resistant P aeruginosa infections.
中文翻译：
头孢他啶-阿维巴坦与头孢洛扎-他唑巴坦治疗美国多重耐药铜绿假单胞菌感染的有效性 （CACTUS）：一项多中心、回顾性、观察性研究
头孢洛扎-他唑巴坦和头孢他啶-阿维巴坦是多重耐药铜绿假单胞菌感染的首选治疗选择;然而，现实世界的比较有效性研究很少。药物之间的药代动力学和药效学差异可能会影响临床反应率。我们旨在比较头孢洛扎-他唑巴坦和头孢他啶-阿维巴坦治疗侵袭性多重耐药铜绿假单胞菌感染的有效性。
更新日期：2024-12-16
中文翻译：
头孢他啶-阿维巴坦与头孢洛扎-他唑巴坦治疗美国多重耐药铜绿假单胞菌感染的有效性 （CACTUS）：一项多中心、回顾性、观察性研究
头孢洛扎-他唑巴坦和头孢他啶-阿维巴坦是多重耐药铜绿假单胞菌感染的首选治疗选择;然而，现实世界的比较有效性研究很少。药物之间的药代动力学和药效学差异可能会影响临床反应率。我们旨在比较头孢洛扎-他唑巴坦和头孢他啶-阿维巴坦治疗侵袭性多重耐药铜绿假单胞菌感染的有效性。
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