In this study, a mixed model was applied to the marine medaka to investigate the intergenerational effects of parental exposure to Triphenyltin (TPT) and the subsequent perturbations in parental gut microbiota on the gut microbiota of offspring. In addition, “microgenderome” has been focused on elucidating the different responses of males and females to environmental stress. The results indicated that TPT exhibited androgenic effects and long-term toxicological consequences, influencing the internal steroid hormone levels of the offspring and leading to their abnormal growth and development. Furthermore, the “microgenderome” has been observed in fish, which resulted in sex-specific responses among females and males when exposed to TPT. The effects of parental TPT exposure on offspring also varied by sex; specifically, it disrupted the intestinal microenvironment in female offspring, creating selective pressure on gut microbiota. In contrast, the male gut microbiota exhibited greater sensitivity to environmental perturbations, allowing rapid community interactions to achieve a relatively stable state. These findings suggest that TPT poses significant long-term toxicological effects that warrant further attention and management. Moreover, the identification of the “microgenderome” phenomenon in fish may provide new insights into gut microbiota disruption and its functional implications.

中文翻译：

---

三苯基丁对海洋青鳉 （Oryzias melastigma） 肠道微生物群的性别特异性影响和代际影响


在这项研究中，将混合模型应用于海洋青鳉，以研究父母暴露于三苯基丁 （TPT） 的代际影响以及随后父母肠道微生物群的扰动对后代肠道微生物群的影响。此外，“微性别组”一直专注于阐明男性和女性对环境压力的不同反应。结果表明，TPT 表现出雄激素作用和长期毒理学后果，影响后代体内类固醇激素水平并导致其异常生长发育。此外，已在鱼类中观察到“微性别组”，这导致雌性和雄性在暴露于 TPT 时出现性别特异性反应。父母 TPT 暴露对后代的影响也因性别而异;具体来说，它破坏了女性后代的肠道微环境，对肠道微生物群产生选择性压力。相比之下，雄性肠道微生物群对环境扰动表现出更高的敏感性，允许快速的群落互动达到相对稳定的状态。这些发现表明 TPT 具有显着的长期毒理学影响，值得进一步关注和管理。此外，在鱼类中鉴定“微性别组”现象可能为肠道微生物群破坏及其功能影响提供新的见解。