Using a SbCl₃/O₂ mild oxidation system, a dual functionalization of the α,β-C–H bonds in alanine ester derivatives was achieved via enamine–imine tautomerism, and a series of quinoline-4-carboxylates were synthesized through a fragmentation–reassembly pathway. The investigation of the substrate scope revealed that various functional groups were easily tolerated, highlighting that this reaction provided an efficient path for the construction of the quinoline-4-carboxylate framework.

中文翻译：

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通过 Enamine-亚胺互变异构作用实现丙氨酸酯衍生物中 α，β-C-H 键的双重功能化：通过碎裂-重组途径构建 4-喹啉酸骨架


使用 SbCl₃/O₂ 轻度氧化系统，通过 enamine-亚胺互变异构实现了丙氨酸酯衍生物中 α，β-C-H 键的双重官能化，并通过碎裂-重组途径合成了一系列喹啉-4-羧酸盐。对底物范围的调查表明，各种官能团很容易耐受，突出表明该反应为构建喹啉-4-羧酸盐框架提供了有效的途径。