New plug-flow opportunities for carrying out S_NAr reactions are disclosed using water mixed with the green and separable/recyclable cosolvent 2-MeTHF. This approach enables C–O, C–N, and C–S bond formations. Several features characteristic of this sustainable technology are highlighted, such as recycling of the aqueous reaction medium, applications to several intermediates en route to numerous active pharmaceutical ingredients, and a new “flow-to-batch-to-flow” sequence of reactions demonstrating the possibilities for both time and pot economies to be realized.

中文翻译：

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使用连续活塞流的 SNAr 反应...在水性双相介质中


使用水与绿色和可分离/可回收的助溶剂 2-MeTHF 混合，揭示了进行 S_NAr 反应的新活塞流机会。这种方法能够形成 C-O、C-N 和 C-S 键。强调了这种可持续技术的几个特点，例如水性反应介质的回收、在多种活性药物成分的途中应用于多种中间体，以及新的“流-批-流”反应序列，展示了实现时间和罐经济的可能性。