The introduction of multiple trifluoromethyl (CF₃) groups into aromatic compounds remains a significant challenge in synthetic chemistry. Here, we report an unprecedented visible light-promoted multiple trifluoromethylation of phenols using commercially available CF₃I. The key to success lies in our discovery of a “continuous activation strategy” that enables sequential trifluoromethylations through single-electron transfer from photoexcited phenoxide to CF₃I until all ortho or para positions are occupied. This practical method provides access to previously inaccessible multi-CF₃-substituted phenols under mild conditions, opening revolutionary possibilities for the design of fluorine-containing functional materials.

中文翻译：

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连续激活苯氧化物和 CF3I 以进行多种三氟甲基化


在芳香族化合物中引入多个三氟甲基 （CF₃） 基团仍然是合成化学中的一个重大挑战。在这里，我们报道了使用市售 CF₃I 的前所未有的可见光促进酚的多重三氟甲基化。成功的关键在于我们发现了一种“连续激活策略”，该策略通过从光激发苯氧到 CF₃I 的单电子转移实现连续的三氟甲基化，直到所有邻位或对位位置都被占据。这种实用的方法提供了在温和条件下以前无法获得的多 CF₃-取代酚，为含氟功能材料的设计开辟了革命性的可能性。