The Front Cover showcases the modernization of the Ritter reaction by photo- and electrochemical methods. Historically, carbocation intermediates in Ritter reactions are achieved under strongly acidic conditions that are functional group intolerant. The Review by C. Pratley, J. P. Barham and co-workers (DOI: 10.1002/ejoc.202400840) describes modern radical methods to access carbocation intermediates that allow the expansion of Ritter chemistry to more complex molecules. Radical intermediates, generated photochemically or electrochemically, undergo oxidative radical polar crossover to carbocations that partake in Ritter chemistry to give amidated products. Oxidative radical polar crossover is the “knight's shining armour” (“Ritter” is German for “knight”). Image created by Sarah S. Coutts.

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封面：新旧概念的融合：通过多组分光和电化学过程的串联氧化自由基-极叉 Ritter 酰胺化 （Eur. J. Org. Chem. 45/2024）


封面展示了通过光化学和电化学方法实现 Ritter 反应的现代化。从历史上看，Ritter 反应中的碳阳离子中间体是在官能团不耐受的强酸性条件下实现的。C. Pratley、J. P. Barham 及其同事的综述 （DOI： 10.1002/ejoc.202400840） 描述了获得碳阳离子中间体的现代自由基方法，这些方法允许将 Ritter 化学扩展到更复杂的分子。通过光化学或电化学生成的自由基中间体经历氧化自由基极叉到碳阳离子，碳阳离子参与 Ritter 化学反应，得到酰胺化产物。氧化自由基极叉是“骑士的闪亮盔甲”（“Ritter”在德语中是“骑士”的意思）。图片由 Sarah S. Coutts 创建。