Radiation-induced caries is the most frequent adverse reaction for patients undergoing radiation treatment for neck and head malignancies. An understanding of how radiation exposure alters tooth structure can lead to the advancement of robust and efficient restorative dentistry approaches. In this work, chemical compositions along with microstructural characteristics of radiation-induced caries-affected dentin have been contrasted to those of both radiation-irradiated and healthy dentin. The specimens of radiation-affected carious dentin and surrounding irradiated dentin were obtained from patients undergoing radiation treatment. The control group in this work included healthy dentin that had not been exposed to radiation. Numerous techniques, including energy-dispersive spectroscopy, Fourier transform infrared spectra, X-ray diffraction, and scanning electron microscopy; have been used to study the specimens. Different levels of microstructural degradation were seen in groups of carious and irradiated dentin, according to scanning electron microscopy. An investigation using energy-dispersive spectroscopy revealed that the carious in addition to irradiated dentin groups had higher quantities of Carbon (with P < 0.05). By contrast, the control group's Calcium and Phosphorus levels were significantly higher (with P < 0.05). In X-ray diffraction analysis, irradiated dentin along with carious dentin samples lacked the (1-1-2) and (3-0-0) peaks, and in Fourier transforms infrared spectroscopy, the carbonate peaks were less prominent. Radiation exposure may decrease hydroxyapatite concentrations, resulting in variable degrees of demineralization as well as degeneration since both irradiated and carious dentin show morphological and chemical changes.

中文翻译：

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放疗对头颈癌患者牙齿结构和龋齿诱导的影响：对修复治疗的影响


放射诱发的龋齿是接受颈部和头部恶性肿瘤放射治疗的患者最常见的不良反应。了解辐射暴露如何改变牙齿结构可以促进稳健和高效的修复牙科方法的发展。在这项工作中，将辐射诱导的龋齿影响牙本质的化学成分和微观结构特征与辐射照射和健康牙本质的化学成分和微观结构特征进行了对比。受辐射影响的龋齿牙本质和周围受辐射的牙本质标本是从接受放射治疗的患者那里获得的。这项工作的对照组包括未暴露于辐射的健康牙本质。多种技术，包括能量色散光谱、傅里叶变换红外光谱、X 射线衍射和扫描电子显微镜;已被用于研究标本。根据扫描电子显微镜，在龋齿和辐照牙本质组中观察到不同程度的微观结构降解。使用能量色散光谱法的调查显示，除辐照牙本质组外，龋齿类组的碳含量较高（P < 0.05）。相比之下，对照组的钙和磷水平明显较高 （P < 0.05）。在 X 射线衍射分析中，辐照牙本质和龋齿牙本质样品缺乏 （1-1-2） 和 （3-0-0） 峰，而在傅里叶变换红外光谱中，碳酸盐峰不太突出。辐射暴露可能会降低羟基磷灰石浓度，导致不同程度的脱矿质和退化，因为受照射和龋齿牙本质都表现出形态和化学变化。