6-Fluoro-4-methylcinnoline (IX) has been synthesized in eight steps from 4-fluoroaniline. A series of styryl and pyridylethenyl cinnolines have been prepared from 6-fluoro-4-methylcinnoline (IX), 4-methylcinnoline and 4-methylcinnoline-2-oxide. Furthermore, a series of 4-substituted benzylthiocinnolines have been prepared.

中文翻译：

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肉桂酸化学。十二。合成6-氟-4-甲基cinnoline和其他cinnolines作为潜在的抗肿瘤药物^†

从八氟苯胺分八步合成了6-氟-4-甲基肉桂酸（IX）。由6-氟-4-甲基肉桂啉（IX），4-甲基肉桂碱和4-甲基肉桂碱-2-氧化物制备了一系列的苯乙烯基和吡啶基乙烯基cinnolines。此外，已经制备了一系列的4-取代的苄基硫代肉桂啉。