Considering the circular economy of zero waste, the valorization of deoiled herbs is an emerging method to improve their value. In the present study, the deoiled cake of Mentha arvensis was used for phytochemical investigation and assessed for anticancer activity. Initially, the phytochemical investigation of deoiled cake of corn mint leads to the isolation of nine known compounds belonging to cinnamates, flavonoids, terpenoids, and steroids (1–9). The isolated compounds showed excellent anticancer activity against breast cancer and moderate activity against skin and cervical cancer, and no toxicity was observed against normal kidney cells. Furthermore, the potent compounds (6 & 8) produce oxidative stress in the mitochondria, disrupt the mitochondrial membrane and nuclear structure, and ultimately cause MDA-MB-231 triple-negative breast cancer cells to undergo apoptosis. The western blot analysis showed that compounds 6 & 8 increase the expression of NRF2/HO-1 and intrinsic apoptosis signaling pathway in breast cancer. Together, the deoiled herb of M. arvensis is valorized by using it as an anticancer agent against breast cancer.

中文翻译：

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通过植物化学研究和抗乳腺癌活性对薄荷草本植物进行价值化


考虑到零浪费的循环经济，脱油草药的价值化是提高其价值的新兴方法。在本研究中，使用 Mentha arvensis 的脱油饼进行植物化学研究并评估抗癌活性。最初，对玉米薄荷脱油饼的植物化学研究导致分离出属于肉桂酸盐、类黄酮、萜类化合物和类固醇的 9 种已知化合物 （1–9）。分离的化合物对乳腺癌表现出优异的抗癌活性，对皮肤癌和宫颈癌表现出中等活性，对正常肾细胞无毒性。此外，强效化合物（6和8）在线粒体中产生氧化应激，破坏线粒体膜和核结构，并最终导致MDA-MB-231三阴性乳腺癌细胞发生细胞凋亡。蛋白质印迹分析显示，化合物 6 和 8 增加乳腺癌中 NRF2/HO-1 和内在细胞凋亡信号通路的表达。总之，M. arvensis 的脱油草药通过将其用作对抗乳腺癌的抗癌剂而获得价值。