Metal-organic networks have attracted widespread interest owing to their hybrid physicochemical properties. Natural biomolecules represent attractive building blocks for these materials because of their inherent biological function and high biocompatibility; however, assembling them into coordination network materials, especially nanoparticles (NPs), is challenging. Herein, we exploit the coordination between metal ions and phosphonate groups, which are present in many biomolecules, to form metal-biomolecule network (MBN) NPs in aqueous solution at room temperature. Various phosphonate-containing biomolecules, including plant phytate, DNA, and proteins, were used to assemble MBN NPs with tunable physicochemical properties (e.g., size). In addition to excellent biocompatibility and high cargo-loading efficiency (>95%), these two-component MBN NPs have various biological functionalities, including endosomal escape, immune regulation, and molecular recognition, thus offering advantages over nonbiomolecular-based coordination materials. This work expands our understanding of metal-organic chemistry with the emerging class of metal-biomolecule systems and provides a pathway for incorporating biofunctionalities into advanced coordination materials for diverse fields.

中文翻译：

---

金属-膦酸盐配位形成的金属-生物分子网络纳米颗粒的组装和生物学功能


金属有机网络因其混合物理化学性质而引起了广泛的兴趣。天然生物分子因其固有的生物功能和高生物相容性而成为这些材料有吸引力的组成部分;然而，将它们组装成配位网络材料，尤其是纳米颗粒 （NPs） 是具有挑战性的。在此，我们利用存在于许多生物分子中的金属离子和膦酸盐基团之间的配位，在室温下在水溶液中形成金属-生物分子网络 （MBN） NPs。使用各种含膦酸盐的生物分子，包括植物植酸盐、DNA 和蛋白质，组装具有可调物理化学性质（例如大小）的 MBN NP。除了优异的生物相容性和高载货效率 （>95%） 外，这些双组分 MBN NPs 还具有多种生物学功能，包括内体逃逸、免疫调节和分子识别，因此比非生物分子配位材料更具优势。这项工作通过新兴的金属-生物分子系统扩展了我们对金属-有机化学的理解，并为将生物功能整合到不同领域的高级配位材料中提供了一条途径。