Human cases of avian influenza A(H5N2) and A(H5N1) viruses associated with outbreaks in birds and mammals are increasing globally, raising concerns about the possibility of a future avian influenza pandemic. We conducted a systematic review examining 30 reported cases of avian influenza in pregnant women. We found high mortality rates for mothers (90.0%, 27/30) and their babies (86.7%, 26/30) when women were infected with avian influenza virus during pregnancy. Despite being a high-risk population and having worse health outcomes across multiple pandemics, pregnant women are often excluded from vaccine trials. However, as the risk for a new pandemic increases and human vaccines against avian influenza are developed, early inclusion of pregnant women in clinical trials can inform the risk-benefit analysis for both the mother and their newborn infant. Early inclusion of pregnant women in public health vaccination programs is vital for protecting this high-risk population.

中文翻译：

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妊娠期禽流感病毒感染和结局的系统评价。


与鸟类和哺乳动物暴发相关的甲型H5N2和甲型H5N1禽流感病毒人间病例在全球范围内不断增加，这引起了人们对未来可能发生禽流感大流行的担忧。我们进行了一项系统评价，检查了 30 例报告的孕妇禽流感病例。我们发现，当女性在怀孕期间感染禽流感病毒时，母亲 （90.0%，27/30） 和婴儿 （86.7%，26/30） 的死亡率很高。尽管孕妇是高危人群，并且在多次大流行中健康状况较差，但她们经常被排除在疫苗试验之外。然而，随着新大流行风险的增加和针对禽流感的人用疫苗的开发，将孕妇早期纳入临床试验可以为母亲及其新生儿的风险-获益分析提供信息。尽早将孕妇纳入公共卫生疫苗接种计划对于保护这一高危人群至关重要。