The unstable antimicrobial activity of antimicrobial peptides (AMPs) under physiological conditions (especially the degradation instigated proteases) seems to be a persistent impediment for their successful implementation in clinical trials. Consequently, our objective was to devise AMP engineering frameworks that could sustain robust antibacterial efficacy within physiological environments.

中文翻译：

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理想化两亲物与蛋白酶抑制剂的结合：赋予生理条件下具有稳定抗菌活性的抗菌肽对抗多重耐药菌


抗菌肽 （AMPs） 在生理条件下（尤其是降解激发的蛋白酶）不稳定的抗菌活性似乎是它们在临床试验中成功实施的持续障碍。因此，我们的目标是设计能够在生理环境中保持强大抗菌功效的 AMP 工程框架。