Host–guest interactions have been increasingly explored for use in the dynamic physical cross-linking of polymeric precursors to form hydrogel networks. However, the orientation of guest motifs is restricted upon macromolecule conjugation. The implications of such restriction on both the kinetics and thermodynamics of the resulting host–guest supramolecular cross-links are poorly understood. Herein, guest cross-linking motifs from controlled regioisomers are demonstrated to yield distinct material properties. Moreover, the underlying phenomena point to a further unexpected impact of modular guest topology on the molecular scale in both the affinity and dynamics of supramolecular complex formation.

中文翻译：

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客体定向对主客体超分子水凝胶的影响


主客体相互作用已被越来越多地探索用于聚合物前驱体的动态物理交联以形成水凝胶网络。然而，客体基序的方向在大分子偶联时受到限制。这种限制对所得主客体超分子交联的动力学和热力学的影响知之甚少。在此，来自受控区域异构体的客体交联基序被证明可产生不同的材料特性。此外，潜在现象表明，模块化客体拓扑结构对超分子复合物形成的亲和力和动力学的分子尺度产生了进一步的意想不到的影响。