Objective Calcium pyrophosphate deposition (CPPD) disease is associated with an increased risk for cardiovascular (CV) events. We examined the atherosclerotic burden by coronary artery calcium (CAC) scores (Agatston score) and compared 10-year atherosclerotic CV disease (ASCVD) risk scores in patients with vs without chondrocalcinosis, a radiographic marker of CPPD. Methods We performed a cross-sectional analysis at an academic medical centre, 1991–2022. Among all patients with an Agatston score in routine care, we defined a cohort with chondrocalcinosis detected before the CAC scan. Comparators without chondrocalcinosis were matched 2:1 on age and sex—the primary analysis excluded statin users. We compared Agatston scores between the chondrocalcinosis cohort and comparators. We also tested for differences between cohorts in 10-year ASCVD risk score frequencies (low, borderline/intermediate or high). Results 756 patients with chondrocalcinosis were matched to 1554 comparators (mean age 68 years, 53% female). CV risk factor burden was high in both cohorts, and statin use was infrequent. The unadjusted Agatston score was non-significantly higher in the chondrocalcinosis cohort (mean 359.1, s.d. 737.9) than in matched comparators (mean 297.1, s.d. 644.9) (P = 0.08). High 10-year ASCVD risk scores were significantly more common in the chondrocalcinosis cohort than comparators (P < 0.01). Conclusion Coronary atherosclerosis burden by CAC was not significantly different between patients with chondrocalcinosis and matched comparators, though 10-year ASCVD risk scores were higher in the chondrocalcinosis cohort, suggesting that factors beyond coronary artery calcification contribute to the increased CV event rate in patients with CPPD disease.

中文翻译：

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焦磷酸钙沉积病患者的冠状动脉钙化和动脉粥样硬化性心血管疾病风险评分


目的 焦磷酸钙沉积 （CPPD） 疾病与心血管 （CV） 事件风险增加相关。我们通过冠状动脉钙化 （CAC） 评分 （Agatston 评分） 检查动脉粥样硬化负荷，并比较了软骨钙质沉着症患者与无软骨钙质沉着症患者的 10 年动脉粥样硬化 CV 风险评分，软骨钙质沉着症是 CPPD 的放射学标志物。方法 我们于 1991-2022 年在学术医学中心进行了横断面分析。在所有常规护理中 Agatston 评分的患者中，我们定义了一个在 CAC 扫描前检测到软骨钙质沉着症的队列。无软骨钙质沉着症的对照组在年龄和性别上以 2：1 匹配——主要分析排除了他汀类药物使用者。我们比较了软骨钙质沉着症队列和对照组之间的 Agatston 评分。我们还测试了队列之间 10 年 ASCVD 风险评分频率 （低、临界/中等或高） 的差异。结果 将 756 例软骨钙质沉着症患者与 1554 例对照者 （平均年龄 68 岁，53% 为女性） 相匹配。两个队列的 CV 危险因素负担都很高，并且他汀类药物的使用不频繁。软骨钙质沉着症队列中未调整的 Agatston 评分 （平均值 359.1， s.d. 737.9） 无统计学意义高于匹配的对照组 （平均值 297.1， s.d. 644.9） （P = 0.08）。与对照组相比，软骨钙质沉着症队列中 10 年 ASCVD 风险评分高更常见 （P < 0.01）。结论 CAC 引起的冠状动脉粥样硬化负担在软骨钙质沉着症患者和匹配的对照组之间没有显著差异，尽管软骨钙质沉着症队列的 10 年 ASCVD 风险评分更高，表明冠状动脉钙化以外的因素导致 CPPD 疾病患者 CV 事件发生率增加。