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Diverse phage communities are maintained stably on a clonal bacterial host
Science ( IF 44.7 ) Pub Date : 2024-12-12 , DOI: 10.1126/science.adk1183
Nora C. Pyenson, Asher Leeks, Odera Nweke, Joshua E. Goldford, Jonas Schluter, Paul E. Turner, Kevin R. Foster, Alvaro Sanchez

Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, we discovered that phage diversity consistently outstripped the diversity of their bacterial hosts under simple experimental conditions. We assembled and passaged dozens of diverse phage communities on a single, nonevolving strain of Escherichia coli until the phage communities reached equilibrium. In all cases, we found that two or more phage species coexisted stably, despite competition for a single, clonal host population. Phage coexistence was supported through host phenotypic heterogeneity, whereby bacterial cells adopting different growth phenotypes served as niches for different phage species. Our experiments reveal that a rich community ecology of bacteriophages can emerge on a single bacterial host.

中文翻译:


在克隆细菌宿主上稳定维持不同的噬菌体群落



噬菌体是地球上最丰富、系统发育最多样化的生物实体,但维持这种非凡多样性的生态机制仍不清楚。在这项研究中,我们发现在简单的实验条件下,噬菌体多样性始终超过其细菌宿主的多样性。我们在单一的、未进化的大肠杆菌菌株上组装并传代了数十种不同的噬菌体群落,直到噬菌体群落达到平衡。在所有情况下,我们发现两种或多种噬菌体物种稳定共存,尽管竞争单个克隆宿主种群。通过宿主表型异质性支持噬菌体共存,其中采用不同生长表型的细菌细胞作为不同噬菌体物种的生态位。我们的实验表明,在单个细菌宿主上可以出现丰富的噬菌体群落生态。
更新日期:2024-12-12
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