BACKGROUND Previous epidemiologic studies of autoimmune diseases in the United States (US) have included a limited number of diseases or used meta-analyses that rely on different data collection methods and analyses for each disease. METHODS To estimate the prevalence of autoimmune diseases in the US, we used electronic health record data from six large medical systems in the US. We developed a software program using common methodology to compute the estimated prevalence of autoimmune diseases alone and in aggregate that can be readily used by other investigators to replicate or modify the analysis over time. RESULTS Our findings indicate that over 15 million people, or 4.6% of the US population, have been diagnosed with at least one autoimmune disease from January 1, 2011, to June 1, 2022, and 34% of those are diagnosed with more than one autoimmune disease. As expected, females (63% of those with autoimmune disease) were almost twice as likely as males to be diagnosed with an autoimmune disease. We identified the top 20 autoimmune diseases based on prevalence and according to sex and age. CONCLUSION Thus, we provide, for the first time, a large-scale prevalence estimate of autoimmune disease in the US by sex and age. FUNDING Autoimmune Registry Inc., the National Heart Lung and Blood Institute, the National Center for Advancing Translational Sciences, the Intramural Research Program of the National Institute of Environmental Health Sciences.

中文翻译：

---

使用电子健康记录数据估计美国自身免疫性疾病的患病率。


背景 美国 （US） 先前的自身免疫性疾病流行病学研究包括有限数量的疾病，或使用依赖于不同数据收集方法和每种疾病分析的荟萃分析。方法 为了估计美国自身免疫性疾病的患病率，我们使用了来自美国六个大型医疗系统的电子健康记录数据。我们使用通用方法开发了一个软件程序来单独和汇总计算自身免疫性疾病的估计患病率，其他研究人员可以很容易地使用它来随着时间的推移复制或修改分析。结果我们的研究结果表明，从 2011 年 1 月 1 日到 2022 年 6 月 1 日，超过 1500 万人（占美国人口的 4.6%）被诊断出患有至少一种自身免疫性疾病，其中 34% 的人被诊断出患有不止一种自身免疫性疾病。正如预期的那样，女性（占自身免疫性疾病患者的 63%）被诊断出患有自身免疫性疾病的可能性几乎是男性的两倍。我们根据患病率、性别和年龄确定了排名前 20 位的自身免疫性疾病。结论 因此，我们首次提供了按性别和年龄划分的美国自身免疫性疾病患病率的大规模估计。资助 自身免疫登记公司、国家心肺和血液研究所、国家促进转化科学中心、国家环境健康科学研究所的校内研究计划。