Iron retention is commonly observed in atherosclerotic plaques and is believed to be detrimental to atherosclerosis. Platelet P2Y12 is a target of antiplatelet therapy in preventing thrombotic complications of atherosclerosis. The protective effect of P2Y12 on hematopoiesis reported by our previous work implies the involvement of P2Y12 in iron metabolism.

中文翻译：

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巨噬细胞 P2Y12 调节铁转运，其抑制作用可防止动脉粥样硬化


铁潴留常见于动脉粥样硬化斑块，被认为对动脉粥样硬化有害。血小板 P2Y12 是抗血小板治疗预防动脉粥样硬化血栓并发症的靶点。我们之前的工作报道的 P2Y12 对造血的保护作用意味着 P2Y12 参与铁代谢。