We have previously demonstrated that RRP15 (Ribosomal RNA Processing 15 Homolog) was significantly elevated in hepatocellular carcinoma (HCC) and correlated directly with poor prognosis. RRP15 suppression curtails HCC progression through induction of cellular senescence and apoptosis. However, the impact of RRP15 on the precise therapeutic potential of lenvatinib has remained underexplored.

中文翻译：

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KBTBD8/RRP15 作为潜在的新型治疗靶点与乐伐替尼抑制的肝细胞癌体外和体内进展相关


我们之前已经证明，RRP15 （核糖体 RNA 加工 15 同源物） 在肝细胞癌 （HCC） 中显着升高，并且与不良预后直接相关。RRP15 抑制通过诱导细胞衰老和细胞凋亡来抑制 HCC 进展。然而，RRP15 对 lenvatinib 精确治疗潜力的影响仍未得到充分探索。