As the proportion of the aging population globally is surging year by year, age-associated diseases, including neurodegenerative, metabolic, and cardiovascular diseases, have recently attracted widespread attention of food scientists and nutritionists. Polymethoxyflavonoids (PMFs), a type of dietary flavonoids, have emerged as potential antiaging candidates owing to their diverse bioactivities, encompassing antioxidant, anti-inflammatory, neuroprotective, and metabolic regulatory effects. Herein, this comprehensive updated review has summarized and discussed the effects of PMFs on aging, and the possible mechanisms that link PMFs-mediated modulation and the prevention or treatment of various aging-related diseases have been elaborated in detail. Furthermore, the biological fate of PMFs have been discussed elaborately from their absorption, distribution, metabolism, and excretion in vivo. Special attention is given to the bioavailability–bioactivity relationship of PMFs, as PMF’s biological activity is significantly hampered by poor bioavailability. Overall, all of these conclusions may help in providing a perspective for further study of PMFs on aging.

中文翻译：

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柑橘多甲氧基黄酮调节衰老相关疾病：负责其调节的生物学机制的进展


随着全球老龄化人口比例逐年激增，包括神经退行性疾病、代谢疾病和心血管疾病在内的与年龄相关的疾病最近引起了食品科学家和营养学家的广泛关注。多甲氧基类黄酮 （PMF） 是一种膳食类黄酮，由于其多种生物活性（包括抗氧化、抗炎、神经保护和代谢调节作用）而成为潜在的抗衰老候选者。在此，本综述全面总结和讨论了 PMFs 对衰老的影响，并详细阐述了将 PMFs 介导的调节与预防或治疗各种衰老相关疾病联系起来的可能机制。此外，PMF 的生物学命运已经从它们在体内的吸收、分布、代谢和排泄方面进行了详细的讨论。特别关注 PMF 的生物利用度-生物活性关系，因为 PMF 的生物活性受到生物利用度差的严重阻碍。总的来说，所有这些结论都可能有助于为进一步研究 PMF 对衰老的影响提供一个视角。