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Single-modality endocrine therapy versus radiotherapy after breast-conserving surgery in women aged 70 years and older with luminal A-like early breast cancer (EUROPA): a preplanned interim analysis of a phase 3, non-inferiority, randomised trial
The Lancet Oncology ( IF 41.6 ) Pub Date : 2024-12-12 , DOI: 10.1016/s1470-2045(24)00661-2 Icro Meattini MD, Maria Carmen De Santis MD, Luca Visani MD, Prof Marta Scorsetti MD, Alessandra Fozza MD, Bruno Meduri MD, Fiorenza De Rose MD, Elisabetta Bonzano MD, Agnese Prisco MD, Valeria Masiello MD, Eliana La Rocca MD, Ruggero Spoto MD, Carlotta Becherini MD, Gladys Blandino MD, Luca Moscetti MD, Riccardo Ray Colciago MD, Riccardo A Audisio MD, Etienne Brain MD, Saverio Caini PhD, Marije Hamaker MD, Orit Kaidar-Person MD, Matteo Lambertini MD, Livia Marrazzo MSc, Calogero Saieva MD, Tanja Spanic MSc, Vratislav Strnad MD, Sally Wheelwright PhD, Prof Philip M P Poortmans MD, Prof Lorenzo Livi MD, EUROPA Trial Investigators, Icro Meattini, Maria Carmen De Santis, Luca Visani, Marta Scorsetti, Alessandra Fozza, Bruno Meduri, Fiorenza De Rose, Elisabetta Bonzano, Agnese Prisco, Valeria Masiello, Eliana La Rocca, Ruggero Spoto, Carlotta Becherini, Gladys Blandino, Luca Moscetti, Riccardo Ray Colciago, Riccardo A Audisio, Etienne Brain, Saverio Caini, Marije Hamaker, Orit Kaidar Person, Matteo Lambertini, Livia Marrazzo, Tanja Spanic, Vratislav Strnad, Sally Wheelwright, Philip M P Poortmans, Lorenzo Livi, Francesca Martella, Lorenzo Vinante, Sara Ramella, Marco Gatti, Sara Pedretti, Patrizia Vici, Nadia G Di Muzio, Alice Pastorino, Maria Cristina Leonardi, Ivica Ratosa, Jure Verbancic
The Lancet Oncology ( IF 41.6 ) Pub Date : 2024-12-12 , DOI: 10.1016/s1470-2045(24)00661-2 Icro Meattini MD, Maria Carmen De Santis MD, Luca Visani MD, Prof Marta Scorsetti MD, Alessandra Fozza MD, Bruno Meduri MD, Fiorenza De Rose MD, Elisabetta Bonzano MD, Agnese Prisco MD, Valeria Masiello MD, Eliana La Rocca MD, Ruggero Spoto MD, Carlotta Becherini MD, Gladys Blandino MD, Luca Moscetti MD, Riccardo Ray Colciago MD, Riccardo A Audisio MD, Etienne Brain MD, Saverio Caini PhD, Marije Hamaker MD, Orit Kaidar-Person MD, Matteo Lambertini MD, Livia Marrazzo MSc, Calogero Saieva MD, Tanja Spanic MSc, Vratislav Strnad MD, Sally Wheelwright PhD, Prof Philip M P Poortmans MD, Prof Lorenzo Livi MD, EUROPA Trial Investigators, Icro Meattini, Maria Carmen De Santis, Luca Visani, Marta Scorsetti, Alessandra Fozza, Bruno Meduri, Fiorenza De Rose, Elisabetta Bonzano, Agnese Prisco, Valeria Masiello, Eliana La Rocca, Ruggero Spoto, Carlotta Becherini, Gladys Blandino, Luca Moscetti, Riccardo Ray Colciago, Riccardo A Audisio, Etienne Brain, Saverio Caini, Marije Hamaker, Orit Kaidar Person, Matteo Lambertini, Livia Marrazzo, Tanja Spanic, Vratislav Strnad, Sally Wheelwright, Philip M P Poortmans, Lorenzo Livi, Francesca Martella, Lorenzo Vinante, Sara Ramella, Marco Gatti, Sara Pedretti, Patrizia Vici, Nadia G Di Muzio, Alice Pastorino, Maria Cristina Leonardi, Ivica Ratosa, Jure Verbancic
Optimal therapy following breast-conserving surgery in older adults with low-risk, early-stage breast cancer remains uncertain. The EUROPA trial aims to compare the effects of radiotherapy and endocrine therapy as single-modality treatments on health-related quality of life (HRQOL) and ipsilateral breast tumour recurrence (IBTR) outcomes in this population.
中文翻译：
70 岁及以上管腔 A 样早期乳腺癌 （EUROPA） 女性保乳手术后单模式内分泌治疗与放疗的比较：一项 3 期、非劣效性、随机试验的预先计划中期分析
对于患有低风险早期乳腺癌的老年人，保乳手术后的最佳治疗仍不确定。EUROPA 试验旨在比较放疗和内分泌治疗作为单一模式治疗对该人群健康相关生活质量 （HRQOL） 和同侧乳腺肿瘤复发 （IBTR） 结局的影响。
更新日期：2024-12-12
中文翻译：
70 岁及以上管腔 A 样早期乳腺癌 （EUROPA） 女性保乳手术后单模式内分泌治疗与放疗的比较：一项 3 期、非劣效性、随机试验的预先计划中期分析
对于患有低风险早期乳腺癌的老年人，保乳手术后的最佳治疗仍不确定。EUROPA 试验旨在比较放疗和内分泌治疗作为单一模式治疗对该人群健康相关生活质量 （HRQOL） 和同侧乳腺肿瘤复发 （IBTR） 结局的影响。
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